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Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility. Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. systemic toxicity is characterised by progressive loss of consciousness leading to coma inhalation of styrene causes irritation of mucous membranes, coughing and wheezing styrene inhalation may also lead to "styrene sickness", which includes ... Repr. July 2000; Endocrine Journal 47(3):343-7 47(3):343-7 Maternal toxicity and increased fetal mortality have been observed in rats and rabbits exposed to styrene oxide by inhalation. • Category 1B for reproductive toxicity “a presumed human reproductive toxicant” – The SPA undertook a careful assessment of the available scientific data and concluded that the weight of available evidence demonstrates that Styrene is not selectively toxic to development and hence classification for reproductive toxicity is not warranted. He has published over 25 such articles in peer-reviewed journals, including the review article “Styrene Metabolism and Toxicokinetics in the SIRC Review” (1994), and, more recently, “Two Generation Reproduction Study of Styrene by Inhalation in Crl-CD Rats”. Experiments were performed to evalute reproductive and developmental toxicology in rats and rabbits exposed to styrene oxide by inhalation. 2000 Is Peer Reviewed? The reproductive and developmental toxicity of styrene has been studied in animals and humans. The reproductive and developmental toxicity of styrene has been studied in animals and humans. Styrene oxide, like many intermediate metabolites of foodstuffs, is genotoxic and, if introduced directly into the stomachs of rodents in high doses/concentrations, gives rise to cancers of the forestomach. The listing of α-methyl styrene for the endpoint of female reproductive toxicity is effective July 29, 2011. 32 Issue. 3.2.1.1 Death There have been no reports of deaths in humans directly associated with exposure to styrene in the workplace (EPA 1985a; Gosselin et al. An LC This study was conducted to evaluate the potential adverse effects of styrene on reproductive capability from whole‐body inhalation exposure of F 0 and F 1 parental animals. Inhalation of airborne toluene is the main source of human ex- 3 Page Numbers. The characteristic unpleasant smell and low odour threshold (0.1 ppm; 0.43 mg/m3) allows styrene to be readily detected in the workplace at levels below the occupational exposure standards. In light of all the available information, it is concluded that migration of styrene … styrene reproductive toxicity. Toxicity Data 1) Information on adverse effects on human health There is no report on the effects on human health due to exposure to styrene dimer and trimer. Assessments included gonadal function, estrous cyclicity, mating behavior, conception rate, gestation, parturition, lactation, and weaning in the F 0 and F 1 generations, and F 1 generation offspring growth and development. Reproductive performance (i.e. Possible Reproductive Toxicity of Styrene in Peripubertal Male Mice. In animals, inhalation studies indicate that the acute toxicity of styrene is low to moderate. Styrene 100- 42 -5 90 - 100% Yes 3. Toluene is also used as a solvent for paints, lacquers, and adhesives. Yes Journal. In rabbits exposed to styrene ... ated the reproductive toxicity of ethylene oxide, propylene oxide, butylene oxide, and styrene oxide. Nonneoplastic lesions were observed in the brain, thymus, spleen, liver, kidney, and reproductive organs of males and females and were considered due to overt toxicity. One reproductive toxicity study in female workers from the plastic manufacturing industry exposed to 13 or 52 ppm styrene has been negative for menstrual disorders (Lemasters et al., 1985), whereas another study in humans has shown increased frequency of spontaneous abortions and a decreased frequency of births (Lemasters et al., 1989). HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. There are good reasons that the reduction in grip strength is not an indication for a specific developmental effect but is rather attributable to a combination of reduced body weight and chance variations in data. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive … mating behaviour and fertility), gestation length, litter data (number of pups, sex ratio), postnatal survival, sperm evaluations and primordial follicle counts were not adversely affected by styrene exposure across the generations. acute toxicity, hearing damage and is suspected of reproductive toxicity. Reproductive Toxicity… CATEGORY 2: Suspected human reproductive toxicant Substances are classified in Category 2 for reproductive toxicity when there is some evidence from humans or experimental animals, possibly supplemented with other information, of an adverse effect on sexual function and fertility, or on development, and where the evidence is not sufficiently convincing to place the substance in Category 1. EC number: 202-851-5 | CAS number: 100-42-5 . Gary P. Carlson, Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice, Toxicology, 10.1016/j.tox.2012.02.006, 294, 2-3, (104-108), (2012). Styrene-butadiene copolymer 9003-55-8 New Jersey Right to Know Components Styrene-butadiene copolymer 9003-55-8 California Prop. 2) Information on endocrine system and reproductive system (1) in vitro test results related to receptor binding (Attachment-3) Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list. These chemicals include styrene, methyl methacrylate, epoxy resins, vinyl chloride, and others. 1. styrene oxide, a finding suggesting preimplantation loss. A review of the developmental and reproductive toxicity of styrene Author(s) Brown, NA; Lamb, JC; Brown, SM; Neal, BH Year. Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats 98-83-9. Chronic toxicity and reproductive performance were evaluated in groups of rats receiving styrene monomer in their drinking water at nominal concentrations of 0, 125, or 250 ppm. ... We don’t know what causes most fertility problems, miscarriages, birth defects, and other reproductive problems. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure IARC: 2B - Group 2B: Possibly carcinogenic to humans (Styrene) Reproductive toxicity Suspected of damaging the unborn child. noviembre 19, 2020; schließen Weitere Informationen über unsere Verwendung von Cookies. Detailed results of these studies are available from the National Institute for Occupational Safety Acute toxicity * Oral * Dermal * Inhalation Skin corrosion/irritation Serious eye damage/irritation Respiratory sensitization Skin sensitization Carcinogenicity * IARC * OSHA * ACGIH * NTP * EU CLP Germ cell mutagenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard FLAMMABLE LIQUID AND VAPOR. Styrene will polymerise when contaminated by oxidising agents and most halides. The acute toxicity of styrene appears to be unrelated to its biotransformation. The shocking fact about styrene which is the main substance that form our daily styrofoam product made us realize how big is the exposure we already had in our body. The animal studies on styrene have diverse study designs and conclusions. Reproductive and Developmental Toxicity of Toluene: A Review by James M. Donald,* Kim Hooper,* and Claudia ... styrene production and coke-oven operations (4,8). The animal studies on styrene have diverse study designs and conclusions. Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. Reproductive Toxicity Risk Assessment Published on October 31, 1996, Federal Register 61(212):56274-56322 These guidelines replace two proposed guidelines: Proposed Guidelines for Female Reproductive Risk and Proposed Guidelines for Male Reproductive Risk, both dated June 30, 1988. 1984; NIOSH 1983). α-Methyl styrene. Maternal toxicity, increased preimplantation loss of fetuses, reduced fetal weight, and No information is available on the reproductive or developmental effects of styrene oxide in humans. Female reproductive toxicity. 228-247 Language. ... Styrene Group I Chemical High Exposure Concern Not applicable Other Adverse Effects The toxicological properties have not been fully investigated. That is why we gather list of chemicals known to cause cancer or reproductive toxicity below: 1. (Birth Defects Research Part B: Developmental and Reproductive Toxicity, 2005). Female rats were exposed to 100 or 300 ppm styrene oxide or to filtered air for 7 h/day, 5 days/week for 3 weeks. Regulatory Toxicology and Pharmacology ISSN: 0273-2300 EISSN: 1096-0295 Volume. Acute toxicity, Inhalation (Category4), H332 Skin irritation (Category2), H315 Eye irritation (Category 2), H319 Reproductive toxicity (Category 2), H361d Specific target organ toxicity - repeated exposure (Category 1), H372 For the full text of the H-Statementsmentioned in this … known effects of inhalation exposure of humans and animals to styrene. Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system. Hazards Identification Emergency Overview ----- DANGER! Extensive mortality occurred in rats that received prolonged exposure to 100 ppm styrene oxide while 300 ppm was rapidly lethal. Styrene. Tests for reproductive toxicity have given negative results, but effects on blood dopamine and hypothalamic and pituitary function and menstrual cycling under conditions of very high exposure have been reported. ACGIH (2010) Background on listing by the Labor Code mechanism: Health and Safety Code section 25249.8(a) requires that substances identified in Labor Code section 6382(d) as causing reproductive toxicity be included on the Proposition 65 list. Styrene NAC: 02/2008 vii repeated exposure of rats through gestation day 6 – 20 to 300 ppm, an increased neonatal death rate and delayed postnatal development was observed compared to … Suspected human reproductive toxicant Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure Causes damage to organs through prolonged or repeated exposure. Article. 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